Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3
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منابع مشابه
Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3
Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet-bacterium interactions might contribute to some of these conditions; however, mechanisms of human platelet activation by E. coli leading to thrombus formation are poorly understood. While the IgG receptor FcγRIIA has a key role in platelet respon...
متن کاملAmplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4.
Bacterial adhesion to platelets is mediated via a range of strain-specific bacterial surface proteins that bind to a variety of platelet receptors. It is unclear how these interactions lead to platelet activation. We demonstrate a critical role for the immune receptor FcγRIIA, αIIbβ3, and Src and Syk tyrosine kinases in platelet activation by Staphylococcus aureus, Streptococcus sanguinis, Stre...
متن کاملHuman platelet activation by Escherichia coli
Gram-negative Escherichia coli cause diseases such as sepsis and hemolytic uremic syndrome in which thrombotic disorders can be found. Direct platelet–bacterium interactions might contribute to some of these conditions; however, mechanisms of human platelet activation by E. coli leading to thrombus formation are poorly understood. While the IgG receptor FcγRIIA has a key role in platelet respon...
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Calcium and integrin binding protein 1 (CIB1) is a specific binding partner for the cytoplasmic domain of the αIIb subunit of the highly abundant platelet integrin αIIbβ3. This protein has been suggested to be involved in the regulation of the activation of αIIbβ3, a process leading to platelet aggregation and blood coagulation. In this work, the solution structure of the deuterated Ca(2+)-CIB1...
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word count: 196 Text word count: 3665 Heading: Hematopoiesis Blood First Edition Paper, prepublished online May 2, 2006; DOI 10.1182/blood-2005-11-011957 Copyright © 2006 American Society of Hematology For personal use only. on August 31, 2017. by guest www.bloodjournal.org From
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ژورنال
عنوان ژورنال: Platelets
سال: 2016
ISSN: 0953-7104,1369-1635
DOI: 10.3109/09537104.2016.1148129